IgA, IgG, IgMjanuari 25, 2019 | klas | Leave a comment
Doctors often measure IgA, IgG, and IgM together to get a snapshot of your immune function. A lab tech will usually take a sample of your blood by inserting a needle into a vein in your arm.
Immunoglobulin D (IgD), which exists in small amounts in the blood, is the least understood antibody. IgA, IgG, and IgM are often measured together. That way, they can give doctors important information about immune system functioning, especially relating to infection or autoimmune disease.
Quantitative immunoglobulins testing measures the total amount of each primary immunoglobulin class, IgA, IgM, and IgG, without distinguishing between subclasses. Separate testing can be performed to measure immunoglobulin subclasses and/or to detect and measure specific antibodies.
IgM vs IgG. An immunoglobulin or antibody refers to proteins that bind to antigens in specific cases. Both IgM and IgG refer to a class of immunoglobulin. Antibodies are produced by the immune system to fight antigens like bacteria and viruses. IgM refers to those antibodies that are produced immediately after an exposure to the disease, while IgG refers to a later response.
Results will include measurements for Immunoglobulin A (IgA), Immunoglobulin G (IgG) and Immunoglobulin M (IgM). Immunoglobulins, or antibodies, are an important part of the immune system which fight off bacteria, viruses and other foreign organisms.
Elevations of IgG, IgA, and IgM may be due to polyclonal immunoglobulin production. Monoclonal gammopathies of all types may lead to a spike in the gamma globulin zone seen on serum protein electrophoresis. Monoclonal elevations of IgG, IgA, IgD, and IgE characterize multiple myeloma.
Immunoglobulin G (IgG), the most abundant type of antibody, is found in all body fluids and protects against bacterial and viral infections. Immunoglobulin M (IgM) , which is found mainly in the blood and lymph fluid, is the first antibody to be made by the body to fight a new infection.
In serum, IgA exists as monomeric H2L2. The secretory component is a polypeptide synthesized by epithelial cells that assist IgA passage to the mucosal surface. It also protects IgA from degradation in the intestinal tract.
Elevations of IgG, IgA, and IgM may be due to polyclonal immunoglobulin production. Monoclonal gammopathies of all types may lead to a spike in the gamma globulin zone seen on serum protein electrophoresis.
Conversely, serum IgG and serum IgM levels were higher in females than in males (Table 1). These differences between sexes were observed throughout all age ranges (Fig. 2). Serum IgA and serum IgG levels tended to increase with age (P for trend < 0·001 in both cases). This trend was observed in both sexes (Fig. 2).